Introduction

Rheumatoid factor (RF) is an autoantibody that targets the body's own tissues, leading to inflammation and joint damage. It is commonly associated with rheumatoid arthritis (RA) but may also be elevated in other autoimmune and inflammatory conditions.

Clinical Importance

Used primarily in diagnosing rheumatoid arthritis.

Helps differentiate RA from other forms of arthritis and joint disorders.

Can indicate other autoimmune diseases like Sjögren’s syndrome, lupus, and chronic infections.

Higher RF levels often correlate with more severe RA symptoms and complications.

When is it Done?

Persistent joint pain, swelling, and stiffness lasting more than six weeks.

Suspected cases of rheumatoid arthritis or autoimmune disorders.

Monitoring disease progression and response to treatment in RA patients.

Evaluation of unexplained chronic inflammatory symptoms.